Detalhe da pesquisa
1.
Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity.
Cell
; 177(3): 597-607.e9, 2019 04 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-31002796
2.
Obesity-Associated GNAS Mutations and the Melanocortin Pathway.
N Engl J Med
; 385(17): 1581-1592, 2021 10 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-34614324
3.
Biased Gs versus Gq proteins and ß-arrestin signaling in the NK1 receptor determined by interactions in the water hydrogen bond network.
J Biol Chem
; 290(40): 24495-508, 2015 Oct 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-26269596
4.
The GLP-1R as a model for understanding and exploiting biased agonism in next-generation medicines.
J Endocrinol
; 261(2)2024 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38451873
5.
Low resting metabolic rate and increased hunger due to ß-MSH and ß-endorphin deletion in a canine model.
Sci Adv
; 10(10): eadj3823, 2024 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38446876
6.
Modulation of constitutive activity and signaling bias of the ghrelin receptor by conformational constraint in the second extracellular loop.
J Biol Chem
; 287(40): 33488-502, 2012 Sep 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-22846991
7.
A rare human variant that disrupts GPR10 signalling causes weight gain in mice.
Nat Commun
; 14(1): 1450, 2023 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36922513
8.
Allosteric and orthosteric sites in CC chemokine receptor (CCR5), a chimeric receptor approach.
J Biol Chem
; 286(43): 37543-54, 2011 Oct 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-21878623
9.
The Location of Missense Variants in the Human GIP Gene Is Indicative for Natural Selection.
Front Endocrinol (Lausanne)
; 13: 891586, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35846282
10.
Human loss-of-function variants in the serotonin 2C receptor associated with obesity and maladaptive behavior.
Nat Med
; 28(12): 2537-2546, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36536256
11.
Conserved water-mediated hydrogen bond network between TM-I, -II, -VI, and -VII in 7TM receptor activation.
J Biol Chem
; 285(25): 19625-36, 2010 Jun 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-20395291
12.
Dysregulation of betaglycan expression in primary human endometrial carcinomas.
Cancer Invest
; 29(2): 137-44, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21261473
13.
Expression of endoglin in primary endometrial cancer.
Oncology
; 81(3-4): 243-50, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-22116456
14.
Loss-of-function mutations in the melanocortin 4 receptor in a UK birth cohort.
Nat Med
; 27(6): 1088-1096, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34045736
15.
Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation.
Cell Rep
; 34(12): 108862, 2021 03 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-33761344
16.
Overlapping binding site for the endogenous agonist, small-molecule agonists, and ago-allosteric modulators on the ghrelin receptor.
Mol Pharmacol
; 75(1): 44-59, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18923064
17.
The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones.
Mol Metab
; 19: 49-64, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30472415
18.
[TGF beta signalling accessory receptors]. / Receptory pomocnicze w sygnalizacji TGF beta.
Postepy Biochem
; 54(3): 264-73, 2008.
Artigo
em Polonês
| MEDLINE | ID: mdl-19112825
19.
Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis.
Cell Metab
; 27(2): 419-427.e4, 2018 02 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29414687
20.
MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency.
Nat Med
; 24(5): 551-555, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29736023